RSI was founded in 2009 by John Smothers and his late wife, inspired by their struggles with infertility. Initially, RSI was a passion project, focused on research. In 2017, the company relaunched through the Texas Tech Innovation Hub's Accelerator program, securing grants that revived the dream of bringing their product to market. In 2018, John's wife passed away after a long battle with cancer. Motivated by his promise to honor their dream, John took a leap of faith and dedicated himself full-time to growing RSI. Since then, RSI has remained steadfast in its mission to help with couples' fertility challenges.